Borrowing Nuclear DNA Helicases to Protect Mitochondrial DNA
نویسندگان
چکیده
منابع مشابه
Borrowing Nuclear DNA Helicases to Protect Mitochondrial DNA
In normal cells, mitochondria are the primary organelles that generate energy, which is critical for cellular metabolism. Mitochondrial dysfunction, caused by mitochondrial DNA (mtDNA) mutations or an abnormal mtDNA copy number, is linked to a range of human diseases, including Alzheimer's disease, premature aging and cancer. mtDNA resides in the mitochondrial lumen, and its duplication requir...
متن کاملDNA Helicases
DNA helicases are proteins that use the energy of NTP hydrolysis to processively denature duplex DNA.' As such, helicases can be considered similar to other mechanochemical motors that can catalyze directional movement along a polymeric lattice (e.g., microtubule-based motors as kinesin). Acting during DNA replication, helicases convert the duplex DNA to single strands and thereby activate the ...
متن کاملDna Helicases
In all organisms, genetic information is locked within a double helix formed by the two antiparallel deoxyribonucleic acid (DNA) strands. Although double-stranded DNA (dsDNA) is suitable for secure information storage, hydrogen bonds formed between complementary bases impair readout of this information by the cellular machineries that frequently require single-stranded DNA (ssDNA) as the templa...
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In this paper we consider two populations whose generations are not overlapping and whose size is large. The number of males and females in both populations is constant. Any generation is replaced by a new one and any individual has two parents for what concerns nuclear DNA and a single one (the mother) for what concerns mtDNA. Moreover, at any generation some individuals migrate from the first...
متن کاملUnraveling DNA helicases
DNA helicases are molecular motor enzymes that use the energy of NTP hydrolysis to separate transiently energetically stable duplex DNA into single strands. They are therefore essential in nearly all DNA metabolic transactions. They act as essential molecular tools for the cellular machinery. Since the discovery of the first DNA helicase in Escherichia coli in 1976, several have been isolated f...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2015
ISSN: 1422-0067
DOI: 10.3390/ijms160510870